Drug Dosing
05/22/2012 by jgluvna
Using knowledge about serum levels of certain drugs over time and their latency in the human body, determine the decay rate of a drug in the human body in order to calculate the right amount of that drug that should be administered to patients.
Theory:
- Derivatives of exponential functions (Neuhauser, Claudia. Calculus for Biology and Medicine. New Jersey: Prentice Hall, 2000. 131)
- Pharmacokinetic models (Stephen P. and John Guckenheimer. Dynamic Models in Biology. New Jersey: Princeton University Press, 2006. 13)
- Type of compartment model that addresses the absorption, redistribution, and transformation of drugs or other ingested substances within the body
References:
- Bradshaw-Pierce, E. L. et al. 2008. Pharmacokinetic-directed dosing of vandetanib and docetaxel in a mouse model of human squamous cell carcinoma. Molecular Cancer Therapeutics. 7(9): 3006-3017.
- Hurwitz, S. J. et al. 2008. Development of an Optimized Dose for Coformulation of Zidovudine with Drugs That Select for the K65R Mutation Using a Population Pharmacokinetic and Enzyme Kinetic Simulation Model. Antimicrobial Agents and Chemotherapy. 52(12): 4241-4250.
- Yin, O. Q. P. et al. 2008. A Mechanism-Based Population Pharmacokinetic Model for Characterizing Time-Dependent Pharmacokinetics of Midostaurin and its Metabolites in Human Subjects. Clinical Pharmacokinetics. 47(12): 807-816.